Linked Life Data

21401628

Source:http://linkedlifedata.com/resource/pubmed/id/21401628

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2011-3-15
pubmed:abstractText
Preserving the fertility of women whose reproductive tract function is threatened by disease or disease treatment is a challenge for the assisted reproduction clinic. In particular, the ovary is susceptible to damage by chemo- and radiotherapeutic treatments, as the reserve of primordial follicles is susceptible to damage and death. To overcome this challenge, experimental strategies are being developed where ovarian tissue or an entire ovary is removed and cryopreserved during the patient's treatment. After recovery, the tissue is thawed and reintroduced orthotopically to the patient, in hopes that ovarian function will recover. In complementary approaches, attempts are being made to foster ovarian follicle development in vitro so that mature eggs can be produced. Here, we consider the state of the art of these strategies, and consider the question of whether whole ovary freezing has a place in fertility preservation in the foreseeable future.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1749-6632
pubmed:author
pubmed:copyrightInfo
© 2011 New York Academy of Sciences.
pubmed:issnType
Electronic
pubmed:volume
1221
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Ovarian cryopreservation strategies and the fine control of ovarian follicle development in vitro.
pubmed:affiliation
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA. josh.johnson@yale.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't