Linked Life Data

2140095

Source:http://linkedlifedata.com/resource/pubmed/id/2140095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1990-6-15
pubmed:abstractText
Cardiac and peripheral effects of three calcium antagonists of the dihydropyridine group were compared in three groups of ten men each with coronary heart disease (mean age 56 +/- 6 years). Dosages (by 30 minutes intravenous infusions) were: 2 mg nifedipine in group I, 0.5 mg nisoldipine in group II and 0.5 mg isradipine in group III. In this dosage peripheral effects--decrease of peripheral vascular resistance and mean aortic pressure--did not differ significantly between them. As a consequence of different negative chronotropic properties the extent of the observed reflex tachycardia was different: there was no significant heart rate increase after isradipine, an increase by 9.8% (P less than or equal to 0.001) after nifedipine and by 20.4% (P less than or equal to 0.001) after nisoldipine. Left-ventricular pressure-rise velocity as a parameter of myocardial contractility rose by 15.3% in group II (P less than or equal to 0.001) and by 13.5% in group III (p less than or equal to 0.001), but not in group I. These data show, that peripheral equipotent dosages of the three calcium antagonists can have different myocardial effects.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0012-0472
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
723-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Myocardial effects of the calcium antagonists nifedipine, nisoldipine and isradipine in coronary heart disease].
pubmed:affiliation
Abteilung Innere Medizin III, Medizinische Universitätsklinik und Poliklinik, Tübingen.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Controlled Clinical Trial