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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
30
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pubmed:dateCreated |
2011-7-28
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pubmed:abstractText |
Lung cancer is the most common cause of cancer-related mortality worldwide. Here, we report elevated expression of tribbles homolog 2 (TRIB2) in primary human lung tumors and in non-small cell lung cancer cells that express low levels of differentiation-inducing transcription factor CCAAT/enhancer-binding protein alpha (C/EBP?). In approximately 10-20% of cases, elevated TRIB2 expression resulted from gene amplification. TRIB2 knockdown was found to inhibit cell proliferation and in vivo tumor growth. In addition, TRIB2 knockdown led to morphological changes similar to C/EBP? overexpression and correlated with increased expression and activity of C/EBP?. TRIB2-mediated regulation of C/EBP? was found to occur through the association of TRIB2 with the E3 ligase TRIM21. Together, these data identify TRIB2 as a potential driver of lung tumorigenesis through a mechanism that involves downregulation of C/EBP?.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1476-5594
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3328-35
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pubmed:meshHeading |
pubmed-meshheading:21399661-Animals,
pubmed-meshheading:21399661-CCAAT-Enhancer-Binding Protein-alpha,
pubmed-meshheading:21399661-Cell Line, Tumor,
pubmed-meshheading:21399661-Cell Proliferation,
pubmed-meshheading:21399661-Cell Transformation, Neoplastic,
pubmed-meshheading:21399661-Down-Regulation,
pubmed-meshheading:21399661-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21399661-Gene Knockdown Techniques,
pubmed-meshheading:21399661-Humans,
pubmed-meshheading:21399661-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:21399661-Lung Neoplasms,
pubmed-meshheading:21399661-Mice,
pubmed-meshheading:21399661-RNA, Small Interfering,
pubmed-meshheading:21399661-Ribonucleoproteins
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pubmed:year |
2011
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pubmed:articleTitle |
Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBP?.
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pubmed:affiliation |
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA. bgrandinetti@gnf.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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