Linked Life Data

21398071

Source:http://linkedlifedata.com/resource/pubmed/id/21398071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-5-20
pubmed:abstractText
Most rotavirus gastroenteritis is caused by G1P[8] strains. When G2 infections are encountered, the P type has most often been reported to be P[4]. The purpose of our study was to describe an unusual outbreak of G2P[6] cases. Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for rotavirus antigen in stool by ELISA (with G-typing if ELISA positive) since 1994-1995. Compared to the last 12 rotavirus seasons before the 2006 introduction of a new rotavirus vaccine, the 2005-2006 season had by far the highest number of evaluable rotavirus infections [n = 275 from September 2005 through June 2006, of which 261 (95%) were G typed] and the greatest number of G2 cases (n = 101, 39% of typed strains). Only 16% of G2 strains were associated with P[4], whereas genotype G2P[6] was responsible for 83% of the G2 infections. Eighty-eight percent of the 84 G2P[6] cases occurred in the 60% of patients who were African-Americans, most of whom were urban residents. Among 157 African-American patients, G2 cases (n = 80; 52%) predominated, including 74 due to G2P[6]. Children <6 months old accounted for 27% of cases overall, but 36% of the G2P[6] cases. G2 rotaviruses caused over a third of the community-acquired rotavirus cases in children presenting to CHOP in 2005-2006, attesting to the potential impact of G2 strains during some epidemics. The large majority of G2 strains had the rare P[6] genotype. Urban African-American children under 6 months of age were disproportionately affected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1879-0070
pubmed:author
pubmed:copyrightInfo
Copyright © 2011. Published by Elsevier Inc.
pubmed:issnType
Electronic
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-22
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
An unusual outbreak of rotavirus genotype G2P[6] during the 2005-2006 epidemic season in Philadelphia.
pubmed:affiliation
The Children's Hospital of Philadelphia, Philadelphia, PA, USA. clarkf@email.chop.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't