Linked Life Data

21397720

Source:http://linkedlifedata.com/resource/pubmed/id/21397720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2011-4-25
pubmed:databankReference
pubmed:abstractText
We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, at baseline and 4weeks after immunization in relation to antibody response. We observed higher baseline progenitor and lower monocyte frequencies among week 16 antibody responders. Week 4 decline in MDSC frequency was associated with week 16 antibody response, while administration of GM-CSF was associated with preservation of these cells. No significant differences in GM-CSF receptor expression were observed in the presence vs. absence of GM-CSF. These findings are consistent with a positive role of progenitor cells and a potential negative role of monocytes in vaccine response. Additionally, GM-CSF augmented the preservation of peripheral blood MDSC, which may contribute to the lack of improved vaccine responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-2518
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3558-63
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed-meshheading:21397720-Antibody Formation, pubmed-meshheading:21397720-Antigen-Presenting Cells, pubmed-meshheading:21397720-Antigens, CD14, pubmed-meshheading:21397720-Antigens, CD34, pubmed-meshheading:21397720-CD4-Positive T-Lymphocytes, pubmed-meshheading:21397720-CD8-Positive T-Lymphocytes, pubmed-meshheading:21397720-Female, pubmed-meshheading:21397720-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:21397720-HIV, pubmed-meshheading:21397720-HIV Infections, pubmed-meshheading:21397720-Hematopoietic Stem Cells, pubmed-meshheading:21397720-Hepatitis B Antibodies, pubmed-meshheading:21397720-Hepatitis B Vaccines, pubmed-meshheading:21397720-Humans, pubmed-meshheading:21397720-Male, pubmed-meshheading:21397720-Middle Aged, pubmed-meshheading:21397720-Monocytes, pubmed-meshheading:21397720-Pilot Projects, pubmed-meshheading:21397720-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
pubmed:year
2011
pubmed:articleTitle
Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals.
pubmed:affiliation
Case Western Reserve University, Cleveland, OH 44106, USA. dda3@case.edu
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Clinical Trial, Phase II, Research Support, N.I.H., Extramural