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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2011-6-6
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pubmed:abstractText |
Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission. In patients affected by bipolar disorder rs4680 can influence antidepressant response and the propensity to develop psychotic symptoms, with the Met/Met genotype exerting a protective role. The same genotype could influence other dopamine-associated psychopathological features, such as mania.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1573-2517
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
293-6
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pubmed:meshHeading |
pubmed-meshheading:21397335-Adult,
pubmed-meshheading:21397335-Age of Onset,
pubmed-meshheading:21397335-Alleles,
pubmed-meshheading:21397335-Bipolar Disorder,
pubmed-meshheading:21397335-Catechol O-Methyltransferase,
pubmed-meshheading:21397335-Dopamine,
pubmed-meshheading:21397335-Female,
pubmed-meshheading:21397335-Genetic Predisposition to Disease,
pubmed-meshheading:21397335-Genotype,
pubmed-meshheading:21397335-Homozygote,
pubmed-meshheading:21397335-Humans,
pubmed-meshheading:21397335-Male,
pubmed-meshheading:21397335-Middle Aged,
pubmed-meshheading:21397335-Polymorphism, Genetic,
pubmed-meshheading:21397335-Recurrence
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pubmed:year |
2011
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pubmed:articleTitle |
Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.
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pubmed:affiliation |
Royal Cornhill Hospital, Aberdeen, UK.
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pubmed:publicationType |
Journal Article
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