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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0010055,
umls-concept:C0062068,
umls-concept:C0162857,
umls-concept:C0205217,
umls-concept:C0389995,
umls-concept:C0443306,
umls-concept:C0543467,
umls-concept:C0700124,
umls-concept:C1150423,
umls-concept:C1335631
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pubmed:issue |
2
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pubmed:dateCreated |
2011-7-18
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pubmed:abstractText |
Radial arteries are increasingly used as conduits for coronary artery bypass grafts. However, vasospasm continues to be a major concern in radial artery grafts. Rho kinase plays a critical role in vascular contraction through phosphorylation of the regulatory subunit myosin phosphatase targeting subunit 1 (MYPT1) of the myosin light chain phosphatase to inhibit myosin light chain phosphatase in vascular smooth muscle. The purpose of this study was to evaluate the inhibitory effects of fasudil, a clinically used Rho kinase inhibitor, on Rho kinase activity, myosin light chain phosphorylation, in vitro contraction, and in situ vasospasm in radial arteries of patients undergoing coronary artery bypass grafting surgery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e59-65
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pubmed:meshHeading |
pubmed-meshheading:21397262-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:21397262-Aged,
pubmed-meshheading:21397262-Coronary Artery Bypass,
pubmed-meshheading:21397262-Female,
pubmed-meshheading:21397262-Humans,
pubmed-meshheading:21397262-Injections, Intra-Arterial,
pubmed-meshheading:21397262-Male,
pubmed-meshheading:21397262-Myosin Light Chains,
pubmed-meshheading:21397262-Myosin-Light-Chain Phosphatase,
pubmed-meshheading:21397262-Phosphorylation,
pubmed-meshheading:21397262-Protein Kinase Inhibitors,
pubmed-meshheading:21397262-Radial Artery,
pubmed-meshheading:21397262-Transplantation, Autologous,
pubmed-meshheading:21397262-Vasodilation,
pubmed-meshheading:21397262-rho-Associated Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.
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pubmed:affiliation |
Department of General and Cardiothoracic Surgery, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan. randel@kinbyou.hosp.go.jp
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pubmed:publicationType |
Journal Article
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