Source:http://linkedlifedata.com/resource/pubmed/id/21397168
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2011-3-14
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| pubmed:abstractText |
Standard magnetic resonance imaging can diagnose congenital bilateral perisylvian polymicrogyria, but is limited in explaining the heterogeneous clinical spectrum of the related congenital bilateral perisylvian syndrome, characterized by pseudobulbar dysfunction, developmental delay, and epilepsy. We analyzed arcuate fasciculi using diffusion tensor imaging, a major language tract in the perisylvian region interconnecting the Broca and Wernicke areas, and at high risk of becoming developmentally affected in this condition. Six patients with congenital bilateral perisylvian syndrome underwent diffusion tensor imaging and were evaluated. The arcuate fasciculus was manually isolated, using tractography. The tract was identified in three patients who had developed speech, and whose values for various diffusion parameters were similar to those in age-matched controls (patients/controls means: fractional anisotropy, 0.50/0.52; apparent diffusion coefficient, 0.0022/0.0022 mm(2)/second; P = ns for both). However, in three patients with severe impairment and no speech development, the arcuate fasciculus could not be identified by fiber-tracking. In this small series, the absence of arcuate fasciculi on diffusion tensor imaging correlated with a more severe phenotype, which cannot be appreciated via structural magnetic resonance imaging alone.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1873-5150
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
44
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
270-4
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:21397168-Abnormalities, Multiple,
pubmed-meshheading:21397168-Adolescent,
pubmed-meshheading:21397168-Brain Mapping,
pubmed-meshheading:21397168-Child,
pubmed-meshheading:21397168-Child, Preschool,
pubmed-meshheading:21397168-Developmental Disabilities,
pubmed-meshheading:21397168-Diffusion Tensor Imaging,
pubmed-meshheading:21397168-Female,
pubmed-meshheading:21397168-Humans,
pubmed-meshheading:21397168-Intellectual Disability,
pubmed-meshheading:21397168-Male,
pubmed-meshheading:21397168-Malformations of Cortical Development,
pubmed-meshheading:21397168-Motor Cortex,
pubmed-meshheading:21397168-Neural Pathways,
pubmed-meshheading:21397168-Speech Disorders,
pubmed-meshheading:21397168-Temporal Lobe,
pubmed-meshheading:21397168-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Arcuate fasciculus and speech in congenital bilateral perisylvian syndrome.
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| pubmed:affiliation |
Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA.
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| pubmed:publicationType |
Journal Article
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