| pubmed-article:2139698 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C0443146 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:2139698 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:2139698 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2139698 | pubmed:dateCreated | 1990-6-6 | lld:pubmed |
| pubmed-article:2139698 | pubmed:abstractText | We demonstrate, using a recombinant truncated Fc gamma RII molecule as a probe, the presence of anti-Fc gamma R antibodies in several strains of autoimmune mice. Affinity chromatography on a truncated Fc gamma R column of pooled sera from aged NZB females resulted in isolation of 16 micrograms of IgM per ml of serum, approximately 2% of the total IgM; no anti-Fc gamma R IgM was found in sera from C58/J mice. Mice with high titers of anti-Fc gamma R IgM also had anti-Fc gamma R IgG. Affinity-purified anti-Fc gamma R IgG bound to Fc gamma R-bearing cells. A good correlation was found between the presence of anti-Fc gamma R Ig and impaired phagocytosis of immune complexes in autoimmune strains such as NZB or NZB/NZW F1. Sera with high titers of anti-Fc gamma R Ig from NZB and motheaten mice inhibited the binding of soluble immune complexes. Furthermore, BXSB, a lupus-prone mouse strain that does not produce anti-Fc gamma R Ig, shows normal macrophage binding and phagocytosis of immune complexes. A set of four IgM mAbs that bind to Fc gamma R was identified. These antibodies were polyspecific; some were directed against DNA, and others recognized a wide variety of antigens including histones, thyroglobulin, and transferrin, but all anti-Fc gamma R IgM antibodies effectively inhibited the binding of IgG1 anti-DNP/DNP20BSA complexes to J774 macrophages. The role of anti-Fc gamma R Ig in autoimmunity remains to be established. It may act to crosslink and activate Fc gamma Rs on neutrophils, macrophages, NK, and mesangial cells, or it may desensitize Fc gamma R function of Fc gamma R-bearing cells. | lld:pubmed |
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| pubmed-article:2139698 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2139698 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2139698 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2139698 | pubmed:month | May | lld:pubmed |
| pubmed-article:2139698 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2139698 | pubmed:author | pubmed-author:BonaCC | lld:pubmed |
| pubmed-article:2139698 | pubmed:author | pubmed-author:UnkelessJ CJC | lld:pubmed |
| pubmed-article:2139698 | pubmed:author | pubmed-author:ChenJ MJM | lld:pubmed |
| pubmed-article:2139698 | pubmed:author | pubmed-author:BorosPP | lld:pubmed |
| pubmed-article:2139698 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2139698 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2139698 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:2139698 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2139698 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2139698 | pubmed:pagination | 1581-95 | lld:pubmed |
| pubmed-article:2139698 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2139698 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2139698 | pubmed:articleTitle | Autoimmune mice make anti-Fc gamma receptor antibodies. | lld:pubmed |
| pubmed-article:2139698 | pubmed:affiliation | Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029. | lld:pubmed |
| pubmed-article:2139698 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2139698 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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