Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-6-6
pubmed:abstractText
We demonstrate, using a recombinant truncated Fc gamma RII molecule as a probe, the presence of anti-Fc gamma R antibodies in several strains of autoimmune mice. Affinity chromatography on a truncated Fc gamma R column of pooled sera from aged NZB females resulted in isolation of 16 micrograms of IgM per ml of serum, approximately 2% of the total IgM; no anti-Fc gamma R IgM was found in sera from C58/J mice. Mice with high titers of anti-Fc gamma R IgM also had anti-Fc gamma R IgG. Affinity-purified anti-Fc gamma R IgG bound to Fc gamma R-bearing cells. A good correlation was found between the presence of anti-Fc gamma R Ig and impaired phagocytosis of immune complexes in autoimmune strains such as NZB or NZB/NZW F1. Sera with high titers of anti-Fc gamma R Ig from NZB and motheaten mice inhibited the binding of soluble immune complexes. Furthermore, BXSB, a lupus-prone mouse strain that does not produce anti-Fc gamma R Ig, shows normal macrophage binding and phagocytosis of immune complexes. A set of four IgM mAbs that bind to Fc gamma R was identified. These antibodies were polyspecific; some were directed against DNA, and others recognized a wide variety of antigens including histones, thyroglobulin, and transferrin, but all anti-Fc gamma R IgM antibodies effectively inhibited the binding of IgG1 anti-DNP/DNP20BSA complexes to J774 macrophages. The role of anti-Fc gamma R Ig in autoimmunity remains to be established. It may act to crosslink and activate Fc gamma Rs on neutrophils, macrophages, NK, and mesangial cells, or it may desensitize Fc gamma R function of Fc gamma R-bearing cells.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2450951, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2454251, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2529313, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2659998, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2785132, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2831292, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2883234, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2907509, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2925223, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2941515, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-2941861, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3073180, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3157747, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3166467, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-323399, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3351435, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3534197, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3725434, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-3890479, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-4406686, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6191905, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6227668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6239903, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6370522, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6753724, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6824256, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-6978134, http://linkedlifedata.com/resource/pubmed/commentcorrection/2139698-90108
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
171
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1581-95
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Autoimmune mice make anti-Fc gamma receptor antibodies.
pubmed:affiliation
Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.