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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1990-6-6
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pubmed:abstractText |
The majority of human NK cells express low affinity IgG Fc receptors (CD16+), whereas a minor subset of NK cells lack Fc receptor expression (CD16-). In contrast to CD16+ NK cells that express only p75 IL-2 receptors, CD16- NK cells constitutively co-express both p75 and p55 IL-2 receptors in vivo and preferentially respond to low concentrations of IL-2 with increased cytolytic activation and proliferation. Scatchard analysis demonstrated the presence of approximately 1,200 high affinity (approximately 25 pM kD) and approximately 9,600 intermediate affinity (approximately 2 nM kD) IL-2 receptors on CD16- NK cells. CD16+ NK cells expressed only a single intermediate affinity IL-2 receptor of approximately 1.9 nM kD (approximately 9,000 sites per cell). The IL-2 binding data thus substantiated the phenotypic and functional studies and definitively show that the differential responsiveness of CD16- and CD16+ NK cells to IL-2 is manifested through different affinity IL-2 receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2403487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2467293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2467946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2530273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2784485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-2787381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3086432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3098894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3099289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3108674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3116143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3489062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3489775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3500280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-3871216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2139697-6434688
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1527-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2139697-Antigens, CD,
pubmed-meshheading:2139697-Antigens, Differentiation,
pubmed-meshheading:2139697-Cells, Cultured,
pubmed-meshheading:2139697-Cytotoxicity, Immunologic,
pubmed-meshheading:2139697-Flow Cytometry,
pubmed-meshheading:2139697-Fluorescent Antibody Technique,
pubmed-meshheading:2139697-Humans,
pubmed-meshheading:2139697-Immunoglobulin G,
pubmed-meshheading:2139697-Interleukin-2,
pubmed-meshheading:2139697-Killer Cells, Natural,
pubmed-meshheading:2139697-Kinetics,
pubmed-meshheading:2139697-Receptors, Fc,
pubmed-meshheading:2139697-Receptors, IgG,
pubmed-meshheading:2139697-Receptors, Interleukin-2
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pubmed:year |
1990
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pubmed:articleTitle |
Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.
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pubmed:affiliation |
Becton Dickinson Monoclonal Center, Inc., San Jose, California 95131.
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pubmed:publicationType |
Journal Article
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