|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2011-5-20
|
|
pubmed:abstractText |
Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons are part of the neurobiological substrate that underlies homeostatic sleep regulation. In the present study, we confirmed that sciatic nerve ligation caused thermal hyperalgesia and tactile allodynia in mice. In this experimental model for neuropathic pain, we found an increase in wakefulness and a decrease in non-rapid eye movement sleep under a neuropathic pain-like state. Under these conditions, membrane-bound GABA (?-aminobutyric acid) transporters (GATs) on activated glial fibrillary acidic protein-positive astrocytes were significantly increased in the cingulate cortex, and extracellular GABA levels in this area after depolarization were rapidly decreased by nerve injury. Furthermore, sleep disturbance induced by sciatic nerve ligation was improved by the intracingulate cortex injection of a GAT-3 inhibitor. These findings provide novel evidence that sciatic nerve ligation decreases extracellular-released GABA in the cingulate cortex of mice. These phenomena may, at least in part, explain the insomnia in patients with neuropathic pain. Neuropathic pain-like stimuli suppress the GABAergic transmission with increased GABA (?-aminobutyric acid) transporters located on activated astrocytes in the cingulate cortex related to sleep disturbance.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(2-(tris(4-methoxyphenyl)methoxy)e...,
http://linkedlifedata.com/resource/pubmed/chemical/Anisoles,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Hypnotics and Sedatives,
http://linkedlifedata.com/resource/pubmed/chemical/Midazolam,
http://linkedlifedata.com/resource/pubmed/chemical/Nipecotic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/zolpidem
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1872-6623
|
|
pubmed:author |
pubmed-author:AsatoMegumiM,
pubmed-author:FuruyaMasaharuM,
pubmed-author:ImaiSatoshiS,
pubmed-author:KonnoMichikoM,
pubmed-author:KuzumakiNaokoN,
pubmed-author:MatobaMotohiroM,
pubmed-author:MatsushimaYukiY,
pubmed-author:MiyoshiKanK,
pubmed-author:Nanjo-NiikuraKanaK,
pubmed-author:NaritaMichikoM,
pubmed-author:NaritaMinoruM,
pubmed-author:NiikuraKeiichiK,
pubmed-author:OkutsuDaikiD,
pubmed-author:SaekiMaiM,
pubmed-author:ShimizuToshikazuT,
pubmed-author:SuzukiMasamiM,
pubmed-author:SuzukiTsutomuT,
pubmed-author:TsukiyamaYoshiY,
pubmed-author:YamashitaAkiraA,
pubmed-author:YomiyaKinomiK
|
|
pubmed:copyrightInfo |
Copyright © 2011 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
152
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1358-72
|
|
pubmed:meshHeading |
pubmed-meshheading:21396773-Analysis of Variance,
pubmed-meshheading:21396773-Animals,
pubmed-meshheading:21396773-Anisoles,
pubmed-meshheading:21396773-Disease Models, Animal,
pubmed-meshheading:21396773-Electroencephalography,
pubmed-meshheading:21396773-Electromyography,
pubmed-meshheading:21396773-GABA Plasma Membrane Transport Proteins,
pubmed-meshheading:21396773-Gene Expression Regulation,
pubmed-meshheading:21396773-Glial Fibrillary Acidic Protein,
pubmed-meshheading:21396773-Gyrus Cinguli,
pubmed-meshheading:21396773-Hyperalgesia,
pubmed-meshheading:21396773-Hypnotics and Sedatives,
pubmed-meshheading:21396773-Mice,
pubmed-meshheading:21396773-Mice, Inbred C57BL,
pubmed-meshheading:21396773-Mice, Inbred ICR,
pubmed-meshheading:21396773-Microdialysis,
pubmed-meshheading:21396773-Midazolam,
pubmed-meshheading:21396773-Nipecotic Acids,
pubmed-meshheading:21396773-Pain Measurement,
pubmed-meshheading:21396773-Pain Threshold,
pubmed-meshheading:21396773-Physical Stimulation,
pubmed-meshheading:21396773-Pyridines,
pubmed-meshheading:21396773-RNA, Messenger,
pubmed-meshheading:21396773-Reflex,
pubmed-meshheading:21396773-Sciatic Neuropathy,
pubmed-meshheading:21396773-Sleep Disorders,
pubmed-meshheading:21396773-gamma-Aminobutyric Acid
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
|
|
pubmed:affiliation |
Department of Toxicology, Hoshi University, School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. narita@hoshi.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
