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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-3-14
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pubmed:abstractText |
Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone deacetylase (HDAC) activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Budesonide,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 3 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 4 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridazines,
http://linkedlifedata.com/resource/pubmed/chemical/Rolipram,
http://linkedlifedata.com/resource/pubmed/chemical/Smoke,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/motapizone
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2222
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-46
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pubmed:meshHeading |
pubmed-meshheading:21395877-Aged,
pubmed-meshheading:21395877-Budesonide,
pubmed-meshheading:21395877-Dexamethasone,
pubmed-meshheading:21395877-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21395877-Female,
pubmed-meshheading:21395877-Glucocorticoids,
pubmed-meshheading:21395877-Histone Deacetylases,
pubmed-meshheading:21395877-Humans,
pubmed-meshheading:21395877-Hydrogen Peroxide,
pubmed-meshheading:21395877-Interleukin-8,
pubmed-meshheading:21395877-Macrophage Activation,
pubmed-meshheading:21395877-Macrophages, Alveolar,
pubmed-meshheading:21395877-Male,
pubmed-meshheading:21395877-Oxidants,
pubmed-meshheading:21395877-Oxidative Stress,
pubmed-meshheading:21395877-Phosphodiesterase 3 Inhibitors,
pubmed-meshheading:21395877-Phosphodiesterase 4 Inhibitors,
pubmed-meshheading:21395877-Pyridazines,
pubmed-meshheading:21395877-Rolipram,
pubmed-meshheading:21395877-Smoke,
pubmed-meshheading:21395877-Tobacco,
pubmed-meshheading:21395877-Tumor Necrosis Factor-alpha
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pubmed:year |
2011
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pubmed:articleTitle |
Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages.
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pubmed:affiliation |
Research Unit, University General Hospital Consortium, Valencia, Spain. xmilara@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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