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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-4-21
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pubmed:abstractText |
Recent genome-wide association studies identified a variant rs7575840 in the apolipoprotein B (APOB) gene region as associated with low-density lipoprotein (LDL) cholesterol. However, the underlying functional mechanism of this variant, which resides 6.5 kb upstream of APOB, has remained unknown. Our objective was to investigate rs7575840 for association with refined apoB-containing lipid particles, for replication in a Mexican population, and for its underlying functional mechanism.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, IDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:Aguilar-SalinasCarlos ACA,
pubmed-author:Ala-KorpelaMikaM,
pubmed-author:Cruz-BautistaIvetteI,
pubmed-author:HaasBlake EBE,
pubmed-author:KangasAntti JAJ,
pubmed-author:KuusistoJohannaJ,
pubmed-author:LaaksoMarkkuM,
pubmed-author:NikkolaElinaE,
pubmed-author:PajukantaPäiviP,
pubmed-author:RibaLauraL,
pubmed-author:SoininenPasiP,
pubmed-author:StancakovaAlenaA,
pubmed-author:Tusie-LunaTeresaT,
pubmed-author:VergnesLaurentL,
pubmed-author:Weissglas-VolkovDaphnaD
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1201-7
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pubmed:meshHeading |
pubmed-meshheading:21393584-Adipose Tissue,
pubmed-meshheading:21393584-Aged,
pubmed-meshheading:21393584-Apolipoproteins B,
pubmed-meshheading:21393584-Biological Markers,
pubmed-meshheading:21393584-Case-Control Studies,
pubmed-meshheading:21393584-Cholesterol, LDL,
pubmed-meshheading:21393584-European Continental Ancestry Group,
pubmed-meshheading:21393584-Finland,
pubmed-meshheading:21393584-Gene Frequency,
pubmed-meshheading:21393584-Genetic Predisposition to Disease,
pubmed-meshheading:21393584-Genome-Wide Association Study,
pubmed-meshheading:21393584-Humans,
pubmed-meshheading:21393584-Hypertriglyceridemia,
pubmed-meshheading:21393584-Indians, North American,
pubmed-meshheading:21393584-Linear Models,
pubmed-meshheading:21393584-Lipoproteins, IDL,
pubmed-meshheading:21393584-Lipoproteins, LDL,
pubmed-meshheading:21393584-Lipoproteins, VLDL,
pubmed-meshheading:21393584-Male,
pubmed-meshheading:21393584-Mexico,
pubmed-meshheading:21393584-Middle Aged,
pubmed-meshheading:21393584-Particle Size,
pubmed-meshheading:21393584-Pedigree,
pubmed-meshheading:21393584-Phenotype,
pubmed-meshheading:21393584-Polymorphism, Single Nucleotide,
pubmed-meshheading:21393584-Risk Assessment,
pubmed-meshheading:21393584-Risk Factors,
pubmed-meshheading:21393584-Triglycerides
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pubmed:year |
2011
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pubmed:articleTitle |
Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles.
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pubmed:affiliation |
Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Gonda Center, Rm 6335B, 695 Charles E. Young Dr S, Los Angeles, CA 90095-7088, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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