Linked Life Data

21392984

Source:http://linkedlifedata.com/resource/pubmed/id/21392984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-4-4
pubmed:abstractText
A novel series of spirochromane pan-Akt inhibitors is reported. SAR optimization furnished compounds with improved enzyme potencies and excellent selectivity over the related AGC kinase PKA. Attempted replacement of the phenol hinge binder provided compounds with excellent Akt enzyme and cell activities but greatly diminished selectivity over PKA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2410-4
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Discovery and SAR of spirochromane Akt inhibitors.
pubmed:affiliation
Array BioPharma, Inc., 3200 Walnut Street, Boulder, CO 80301, USA. nkallan@arraybiopharma.com
pubmed:publicationType
Journal Article