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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-3-28
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pubmed:abstractText |
A series of quinolino-benzo-[5, 6]-dihydroisoquindolium compounds (3a, 3f, 3g, and 3j) derived from alkaloid berberine were designed and synthesized as novel G-quadruplex ligands. Subsequent biophysical and biochemical evaluation demonstrated that the addition of pyridine ring and amino group into berberine improved the binding ability and selectivity towards G-quadruplex DNA in comparison with the previously reported 9-N-substituted berberine derivatives. Furthermore, qRT-PCR assay showed compound 3j led the down-regulation of c-myc gene transcription in leukemia cell line HL60, while little effect on normal cell line ECV-304, which was consistent with the behavior of an effective G-quadruplex ligand targeting c-myc oncogene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1768-3254
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1906-13
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pubmed:meshHeading |
pubmed-meshheading:21392861-Antineoplastic Agents,
pubmed-meshheading:21392861-Berberine,
pubmed-meshheading:21392861-Cell Proliferation,
pubmed-meshheading:21392861-Cells, Cultured,
pubmed-meshheading:21392861-DNA,
pubmed-meshheading:21392861-Down-Regulation,
pubmed-meshheading:21392861-Drug Screening Assays, Antitumor,
pubmed-meshheading:21392861-G-Quadruplexes,
pubmed-meshheading:21392861-HL-60 Cells,
pubmed-meshheading:21392861-Humans,
pubmed-meshheading:21392861-Isoquinolines,
pubmed-meshheading:21392861-Ligands,
pubmed-meshheading:21392861-Models, Molecular,
pubmed-meshheading:21392861-Molecular Structure,
pubmed-meshheading:21392861-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:21392861-Quinolines,
pubmed-meshheading:21392861-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:21392861-Stereoisomerism,
pubmed-meshheading:21392861-Thermodynamics,
pubmed-meshheading:21392861-Transcription, Genetic
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pubmed:year |
2011
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pubmed:articleTitle |
Quinolino-benzo-[5, 6]-dihydroisoquindolium compounds derived from berberine: a new class of highly selective ligands for G-quadruplex DNA in c-myc oncogene.
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pubmed:affiliation |
School of Pharmaceutical Sciences, Sun Yat-sen University, Waihuan East Road 132, Guangzhou 510080, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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