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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-5-24
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pubmed:abstractText |
In 12 patients (8 males, 4 females; 59.4 +/- 6.2 years) with clinically manifest atherosclerosis (peripheral vascular disease stage II according to Fontaine and coronary heart disease) without any risk factor and 6 controls (4 males, 2 females; 58.5 +/- 7.06 years) autologous platelets were labelled using 100 microCi 111-In-oxine. In parallel, serum- and plasma-thromboxane (TX) B2 and conversion of exogenous radiolabelled arachidonic acid towards TXB2 were determined. No difference in labelling efficiency and recovery was noted. Platelet half-life was significantly (p less than 0.01) shortened in the atherosclerotics. Gamma-camera images were obtained during the first 64 minutes after reinjection as well as 2, 6, 18, 24 and daily up to 1 week after reinjection of autologous radiolabelled platelets. No difference between the patients suffering from atherosclerosis--having either visible atherosclerotic lesions or not--could be discovered. Serum-TXB2 was comparable, whereas plasma-TXB2 showed a trend towards an increase and the conversion from exogenous 14C-AA to 14C-TXB2 was increased in atherosclerosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane B2,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Thromboglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0049-3848
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
507-16
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2139247-Arachidonic Acid,
pubmed-meshheading:2139247-Arachidonic Acids,
pubmed-meshheading:2139247-Arteriosclerosis,
pubmed-meshheading:2139247-Blood Platelets,
pubmed-meshheading:2139247-Cell Survival,
pubmed-meshheading:2139247-Female,
pubmed-meshheading:2139247-Half-Life,
pubmed-meshheading:2139247-Humans,
pubmed-meshheading:2139247-Male,
pubmed-meshheading:2139247-Middle Aged,
pubmed-meshheading:2139247-Platelet Aggregation,
pubmed-meshheading:2139247-Platelet Count,
pubmed-meshheading:2139247-Platelet Factor 4,
pubmed-meshheading:2139247-Thromboxane B2,
pubmed-meshheading:2139247-beta-Thromboglobulin
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pubmed:year |
1990
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pubmed:articleTitle |
Platelet kinetics in patients with atherosclerosis.
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pubmed:affiliation |
Department of Nuclear Medicine, University of Vienna, Ludwig Boltzmann-Institute for Nuclear Medicine, Austria.
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pubmed:publicationType |
Journal Article
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