Linked Life Data

21391986

Source:http://linkedlifedata.com/resource/pubmed/id/21391986

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-4-11
pubmed:abstractText
Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and to predict adverse outcomes in individuals with cardiovascular disease (CVD). Despite being a member of the same pentraxin protein family as C-reactive protein (CRP), PTX3 probably reflects different aspects of CVD pathogenesis. In this study, we assessed plasma PTX3 correlates and determinants in the Health 2000 Survey population, which comprised n = 403 insulin-resistant subjects, n = 845 hypercholesterolaemic subjects and n = 311 hypertensive subjects, all aged between 46 and 76 years. In insulin-resistant subjects the PTX3 concentration was found to correlate directly with age, pulse pressure and indoleamine 2,3-dioxygenase (IDO) enzyme activity and inversely with total and low-density lipoprotein (LDL) cholesterol. In hypercholesterolaemic subjects, the PTX3 concentration correlated directly with HDL cholesterol, systolic blood pressure and pulse pressure, whereas in hypertensive subjects, the PTX3 concentration correlated directly with systolic blood pressure, pulse pressure and IDO activity. No correlation was observed between the concentrations of PTX3 and CRP, adiposity indicators or indicators of subclinical atherosclerosis in any of the subject groups. PTX3 concentration variations were attributed to variations in LDL cholesterol and IDO activity in insulin-resistant subjects and to pulse pressure in hypercholesterolaemic and hypertensive subjects. These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1365-2249
pubmed:author
pubmed:copyrightInfo
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
pubmed:issnType
Electronic
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-7
pubmed:meshHeading
pubmed-meshheading:21391986-Age Factors, pubmed-meshheading:21391986-Aged, pubmed-meshheading:21391986-Anthropometry, pubmed-meshheading:21391986-Biological Markers, pubmed-meshheading:21391986-Blood Pressure, pubmed-meshheading:21391986-C-Reactive Protein, pubmed-meshheading:21391986-Cardiovascular Diseases, pubmed-meshheading:21391986-Carotid Arteries, pubmed-meshheading:21391986-Cholesterol, pubmed-meshheading:21391986-Cross-Sectional Studies, pubmed-meshheading:21391986-Female, pubmed-meshheading:21391986-Finland, pubmed-meshheading:21391986-Humans, pubmed-meshheading:21391986-Hypercholesterolemia, pubmed-meshheading:21391986-Hypertension, pubmed-meshheading:21391986-Indoleamine-Pyrrole 2,3,-Dioxygenase, pubmed-meshheading:21391986-Insulin Resistance, pubmed-meshheading:21391986-Male, pubmed-meshheading:21391986-Middle Aged, pubmed-meshheading:21391986-Risk Factors, pubmed-meshheading:21391986-Serum Amyloid P-Component
pubmed:year
2011
pubmed:articleTitle
Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey.
pubmed:affiliation
Department of Microbiology and Immunology, Medical School, University of Tampere, Finland. juulia.jylhava@uta.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't