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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-11
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pubmed:abstractText |
We have employed nasal challenge with lipopolysaccharide (LPS) followed by nasal lavage (NL) to experimentally induce and examine upper airway inflammation in human volunteers. It is unclear however whether adaptation within individuals occurs following repeated nasal challenge. This was a pilot study to determine if repeated nasal LPS challenge yields attenuation of markers of inflammation (primarily neutrophil response) in the NL fluid of healthy humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1091-7691
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-7
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pubmed:dateRevised |
2011-8-15
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pubmed:meshHeading |
pubmed-meshheading:21391782-Adolescent,
pubmed-meshheading:21391782-Adult,
pubmed-meshheading:21391782-Antigens, CD14,
pubmed-meshheading:21391782-Biological Markers,
pubmed-meshheading:21391782-Cell Count,
pubmed-meshheading:21391782-Cytokines,
pubmed-meshheading:21391782-Endotoxins,
pubmed-meshheading:21391782-Female,
pubmed-meshheading:21391782-Humans,
pubmed-meshheading:21391782-Immune Tolerance,
pubmed-meshheading:21391782-Interleukin-8,
pubmed-meshheading:21391782-Male,
pubmed-meshheading:21391782-Middle Aged,
pubmed-meshheading:21391782-Nasal Lavage Fluid,
pubmed-meshheading:21391782-Nasal Provocation Tests,
pubmed-meshheading:21391782-Neutrophils,
pubmed-meshheading:21391782-Particulate Matter,
pubmed-meshheading:21391782-Pilot Projects,
pubmed-meshheading:21391782-Respiratory Hypersensitivity,
pubmed-meshheading:21391782-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Nasal PMN response to repeated challenge with endotoxin in healthy volunteers.
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pubmed:affiliation |
Department of Pediatrics, Clinical Fellow, Allergy Immunology, University of North Carolina, Chapel Hill, NC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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