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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-5-23
|
| pubmed:abstractText |
The results of a pilot study employing the administration of intraarterial chemotherapy and accelerated fractionation radiotherapy for advanced gynecologic malignancies are reported. The protocol consisted of three treatment sessions every 3 to 4 weeks. Each session consisted of bilateral or unilateral catheterization of the hypogastric artery with the infusion of cisplatin 100 mg/m2 on Day 1 and 2-deoxy-5-fluorouridine (FUDR) 300 mg/m2 on Day 2. An accelerated fractionation schedule of external-beam radiation was begun on Day 1 consisting of 200 rads twice daily for 4 days (1600 rads per session). Eight patients entered the protocol, and seven completed external-beam radiotherapy. Five completed three intraarterial sessions, and three, two sessions. Five of seven evaluable patients had a complete local response. Local control was sustained fom 6 to 24 months in four patients. Complications included three sensorimotor neuropathies, one clinically insignificant catheter-related thrombosis, and three clinically significant radiation injuries. This multimodality treatment for locally advanced gynecologic tumors appears feasible with modification, and continued work exploring this approach is encouraged.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0090-8258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
55-9
|
| pubmed:dateRevised |
2006-4-24
|
| pubmed:meshHeading |
pubmed-meshheading:2138992-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2138992-Cisplatin,
pubmed-meshheading:2138992-Combined Modality Therapy,
pubmed-meshheading:2138992-Female,
pubmed-meshheading:2138992-Floxuridine,
pubmed-meshheading:2138992-Genital Neoplasms, Female,
pubmed-meshheading:2138992-Humans,
pubmed-meshheading:2138992-Infusions, Intra-Arterial,
pubmed-meshheading:2138992-Neoplasm Staging,
pubmed-meshheading:2138992-Pilot Projects,
pubmed-meshheading:2138992-Radiotherapy Dosage,
pubmed-meshheading:2138992-Survival Rate
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Treatment of advanced gynecologic malignancies with intraarterial chemotherapy and accelerated fractionation radiation therapy: a preliminary report.
|
| pubmed:affiliation |
Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida 33682-0179.
|
| pubmed:publicationType |
Journal Article
|