Linked Life Data

21389261

Source:http://linkedlifedata.com/resource/pubmed/id/21389261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
73
pubmed:dateCreated
2011-3-10
pubmed:abstractText
When treating metastatic tumors, chemoresistance can cause problems. A report in this issue of Science Translational Medicine demonstrates the potential of nanodiamond carriers (2 to 8 nanometers) for treating cancers with drug-efflux-based chemoresistance. Nanodiamond-mediated delivery of the chemotherapeutic doxorubicin (Dox) allowed for prolonged activity and increased apoptosis with decreased toxicity when compared with free Dox in liver cancer cells in culture as well as in vivo in mouse liver tumors. This finding may represent a broadly applicable strategy for overcoming adenosine 5'-triphosphate (ATP)-binding cassette (ABC) drug transporter-mediated resistance during cancer chemotherapy.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1946-6242
pubmed:author
pubmed:issnType
Electronic
pubmed:day
9
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73ps8
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Dodging drug-resistant cancer with diamonds.
pubmed:affiliation
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
pubmed:publicationType
Journal Article, Comment, Research Support, N.I.H., Extramural