| pubmed-article:21389257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0001407 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C1336639 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:21389257 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:21389257 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21389257 | pubmed:dateCreated | 2011-4-5 | lld:pubmed |
| pubmed-article:21389257 | pubmed:abstractText | This study evaluates the ability of a novel TLR7 ligand (9-benzyl-2-butoxy-8-hydroxy adenine, called SA-2) to affect IL-17 response. The SA-2 activity on the expression of IL-17A and IL-17-related molecules was evaluated in acute and chronic models of asthma as well as in in vivo and in vitro ?-galactosyl ceramide (?-GalCer)-driven systems. SA-2 prepriming reduced neutrophils in bronchoalveolar lavage fluid and decreased methacoline-induced airway hyperresponsiveness in murine asthma models. These results were associated with the reduction of IL-17A (and type 2 cytokines) as well as of molecules favoring Th17 (and Th2) development in lung tissue. The IL-17A production in response to ?-GalCer by spleen mononuclear cells was inhibited in vitro by the presence of SA-2. Reduced IL-17A (as well as IFN-? and IL-13) serum levels in mice treated with ?-GalCer plus SA-2 were also observed. The in vitro results indicated that IL-10 produced by B cells and IL-10-promoting molecules such as IFN-? and IL-27 by dendritic cells are the major player for SA-2-driven IL-17A (and also IFN-? and IL-13) inhibition. The in vivo experiments with anti-cytokine receptor Abs provided evidence of an early IL-17A inhibition essentially due to IL-10 produced by resident peritoneal cells and of a delayed IL-17A inhibition sustained by IFN-? and IL-27, which in turn drive effector T cells to IL-10 production. These findings suggest that such TLR7 agonist downregulating Th17 (as well as Th2) response has to be considered a valid candidate for novel vaccine formulations in allergy. | lld:pubmed |
| pubmed-article:21389257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21389257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21389257 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21389257 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:RomagnaniSerg... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:AnnunziatoFra... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:MaggiEnricoE | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:VultaggioAles... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:ParronchiPaol... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:GuarnaAntonio... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:MaggiLauraL | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:NenciniFrance... | lld:pubmed |
| pubmed-article:21389257 | pubmed:author | pubmed-author:PratesiSaraS | lld:pubmed |
| pubmed-article:21389257 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21389257 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21389257 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21389257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21389257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21389257 | pubmed:pagination | 4707-15 | lld:pubmed |
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| pubmed-article:21389257 | pubmed:meshHeading | pubmed-meshheading:21389257... | lld:pubmed |
| pubmed-article:21389257 | pubmed:meshHeading | pubmed-meshheading:21389257... | lld:pubmed |
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| pubmed-article:21389257 | pubmed:meshHeading | pubmed-meshheading:21389257... | lld:pubmed |
| pubmed-article:21389257 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21389257 | pubmed:articleTitle | The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines. | lld:pubmed |
| pubmed-article:21389257 | pubmed:affiliation | Immunoallergology Unit, Careggi Hospital, 50134 Florence, Italy. | lld:pubmed |
| pubmed-article:21389257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21389257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:170743 | entrezgene:pubmed | pubmed-article:21389257 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21389257 | lld:entrezgene |
