| pubmed-article:21389254 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C0872231 | lld:lifeskim |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C0018823 | lld:lifeskim |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C0015915 | lld:lifeskim |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:21389254 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:21389254 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:21389254 | pubmed:dateCreated | 2011-3-22 | lld:pubmed |
| pubmed-article:21389254 | pubmed:abstractText | Tolerance induction toward allogeneic organ grafts represents one of the major aims of transplantation medicine. Stem cells are promising candidates for promoting donor-specific tolerance. In this study, we investigated the immunomodulatory properties of murine embryonic stem cells (ESCs), obtained either by in vitro fertilization (IVF-ESCs) or by nuclear transfer (NT-ESCs), in heart transplant mouse models. IVF-ESCs did not prolong the survival of fully allogeneic cardiac transplants but significantly prolonged the survival of semiallogeneic hearts from the same ESC donor strain for >100 d in 44% of the animals. However, 28% of transplanted animals infused with IVF-ESCs experienced development of a teratoma. NT-ESCs similarly prolonged semiallogeneic heart graft survival (>100 d in 40% of the animals) but were less teratogenic. By in vitro studies, IVF-ESC and NT-ESC immunoregulation was mediated both by cell contact-dependent mechanisms and by the release of soluble factors. By adding specific inhibitors, we identified PGE(2) as a soluble mediator of ESC immunoregulation. Expansion of regulatory T cells was found in lymphoid organs and in the grafts of IVF-ESC- and NT-ESC-tolerized mice. Our study demonstrates that both IVF-ESCs and NT-ESCs modulate recipient immune response toward tolerance to solid organ transplantation, and that NT-ESCs exhibit a lower tendency for teratoma formation. Because NT-ESCs are obtained by NT of a somatic cell from living individuals into an enucleated oocyte, they could represent a source of donor-derived stem cells to induce tolerance to solid organ allograft. | lld:pubmed |
| pubmed-article:21389254 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21389254 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389254 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21389254 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21389254 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21389254 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21389254 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:RemuzziGiusep... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:ZuccottiMauri... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:GaragnaSilvia... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:RediCarlo... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:NorisMarinaM | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:AzzolliniNadi... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:MorigiMarinaM | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:ImbertiBarbar... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:TodeschiniMar... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:CassisPaolaP | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:SebastianoVit... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:CasiraghiFede... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:CuginiDaniela... | lld:pubmed |
| pubmed-article:21389254 | pubmed:author | pubmed-author:SoliniSamanth... | lld:pubmed |
| pubmed-article:21389254 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21389254 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21389254 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21389254 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21389254 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21389254 | pubmed:pagination | 4164-74 | lld:pubmed |
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| pubmed-article:21389254 | pubmed:meshHeading | pubmed-meshheading:21389254... | lld:pubmed |
| pubmed-article:21389254 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21389254 | pubmed:articleTitle | Embryonic stem cells, derived either after in vitro fertilization or nuclear transfer, prolong survival of semiallogeneic heart transplants. | lld:pubmed |
| pubmed-article:21389254 | pubmed:affiliation | Department of Molecular Medicine, Mario Negri Institute for Pharmacological Research, Bergamo 24125, Italy. | lld:pubmed |
| pubmed-article:21389254 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21389254 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:21389254 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
