Linked Life Data

21388972

Source:http://linkedlifedata.com/resource/pubmed/id/21388972

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-10
pubmed:abstractText
The functional interaction between integrin ?6?4 and growth factor receptors has been implicated in key signaling pathways important for cancer cell function. However, few attempts have been made to selectively target this interaction for therapeutic intervention. Previous studies showed that curcumin, a yellow pigment isolated from turmeric, inhibits integrin ?6?4 signaling important for breast carcinoma cell motility and invasion, but the mechanism is not currently known. To address this issue, we tested the hypothesis that curcumin inhibits the functional interaction between ?6?4 and the epidermal growth factor receptor (EGFR). In this study, we found that curcumin disrupts functional and physical interactions between ?6?4 and EGFR, and blocks ?6?4/EGFR-dependent functions of carcinoma cells expressing the signaling competent form of ?6?4. We further showed that curcumin inhibits EGF-dependent mobilization of ?6?4 from hemidesmosomes to the leading edges of migrating cells such as lammelipodia and filopodia, and thereby prevents ?6?4 distribution to lipid rafts where functional interactions between ?6?4 and EGFR occur. These data suggest a novel paradigm in which curcumin inhibits ?6?4 signaling and functions by altering intracellular localization of ?6?4, thus preventing its association with signaling receptors such as EGFR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1538-8514
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
883-91
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Curcumin inhibition of the functional interaction between integrin ?6?4 and the epidermal growth factor receptor.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't