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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-5-9
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pubmed:abstractText |
Lymphocyte subsets defined by monoclonal antibodies were investigated in bone marrow and peripheral blood of 17 patients with rheumatoid arthritis (RA); 13 patients with osteoarthritis or aseptic necrosis served as controls. Patients with RA were found to have a raised OKT 4/8 ratio both in bone marrow and peripheral blood in comparison with the controls. Furthermore, bone marrow of RA showed a lower percentage of OKT 8+ T cells than that of controls. The percentage of HLA-DR+ T cells was higher in bone marrow than in peripheral blood of RA, though a slightly lower percentage was detected in bone marrow than in peripheral blood of controls. Thus T cell subsets in bone marrow of RA differ significantly from those of controls. Patients with RA had a higher OKT 4/8 ratio and a higher percentage of HLA-DR+ T cells in bone marrow than controls, suggesting that T cell subsets in bone marrow of RA are in an immunologically activated state and that T cell subsets are affected by rheumatoid inflammation in bone marrow of RA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-1082782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-1083217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-168488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-2947307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-4548344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-4580484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6213027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6217535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6218204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6224467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6352849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6447249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6457006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6459096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6520829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6798978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6968215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6970781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6976376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6979629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6980416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-6984082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-7020614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138877-94505
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-4967
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
168-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2138877-Adult,
pubmed-meshheading:2138877-Aged,
pubmed-meshheading:2138877-Arthritis, Rheumatoid,
pubmed-meshheading:2138877-Bone Marrow,
pubmed-meshheading:2138877-Female,
pubmed-meshheading:2138877-Flow Cytometry,
pubmed-meshheading:2138877-Fluorescent Antibody Technique,
pubmed-meshheading:2138877-Humans,
pubmed-meshheading:2138877-Male,
pubmed-meshheading:2138877-Middle Aged,
pubmed-meshheading:2138877-T-Lymphocytes,
pubmed-meshheading:2138877-T-Lymphocytes, Regulatory
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pubmed:year |
1990
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pubmed:articleTitle |
Analysis of lymphocyte subsets of bone marrow in patients with rheumatoid arthritis by two colour immunofluorescence and flow cytometry.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Kobe University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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