Linked Life Data

21388381

Source:http://linkedlifedata.com/resource/pubmed/id/21388381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-4-26
pubmed:abstractText
The objective of this work is to quantify and compare the optical clearing efficacy of glucose, propylene glycol, glycerol solutions through the human skin tissue in vivo by calculating permeability coefficient of three solutions. Currently, the permeability coefficient of agent in tissues was extracted from optical coherence tomography (OCT) amplitude data mainly through the OCT signal slope and the OCT amplitude methods. In this study, we report the OCT attenuation coefficient method which is a relatively novel and rarely reported methodology to measure the permeability coefficient during the optical skin clearing procedure. The permeability coefficients for 40% propylene glycol, glucose and glycerol were (2.74 ± 0.05) × 10(-6) cm s(-1), (1.78 ± 0.04) × 10(-6) cm s(-1) and (1.67 ± 0.04) × 10(-6) cm s(-1), respectively. It could be clearly seen that the permeability coefficient of the 40% propylene glycol solution is higher than that of 40% glucose solution, and the permeability coefficient of the 40% glucose solution is higher than that of the 40% glycerol solution. These indicate 40% propylene glycol solution is more effective than others in the human skin in vivo. We then compare and prove consistency of optical clearing efficacy figured out by three different methods.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1751-1097
pubmed:author
pubmed:copyrightInfo
© 2011 The Authors. Photochemistry and Photobiology © 2011 The American Society of Photobiology.
pubmed:issnType
Electronic
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
734-40
pubmed:meshHeading
pubmed:articleTitle
In vivo comparison of the optical clearing efficacy of optical clearing agents in human skin by quantifying permeability using optical coherence tomography.
pubmed:affiliation
MOE Key laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal?University, Guangzhou, Guangdong Province, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't