Linked Life Data

21388190

Source:http://linkedlifedata.com/resource/pubmed/id/21388190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-4-7
pubmed:abstractText
In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 ?g/mL against S. Aureus and 6.25 ?g/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2241-54
pubmed:dateRevised
2011-6-21
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Synthetic mimics of antimicrobial peptides from triaryl scaffolds.
pubmed:affiliation
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural