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rdf:type |
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lifeskim:mentions |
umls-concept:C0002199,
umls-concept:C0004561,
umls-concept:C0021758,
umls-concept:C0086418,
umls-concept:C0205307,
umls-concept:C0439098,
umls-concept:C0851285,
umls-concept:C1414549,
umls-concept:C1515670,
umls-concept:C1552644,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
2
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pubmed:dateCreated |
1990-4-30
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pubmed:abstractText |
Human interleukin 4 (IL-4) upregulates Fc epsilon R2/CD23 expression on the surface of B lymphocytes. Here it is shown that IL-4 induces expression of CD23 mRNA in normal human B lymphocytes whereas recombinant IL-1, IL-2, IL-5, IFN gamma, IFN alpha 2b and semi-purified low molecular weight B cell growth factor were unable to do so. CD23 mRNA expression could be observed in B cells after 6 hr incubation with IL-4 and was maximal for 24-72 hr. Costimulation of the B cells with anti-IgM antibody enhanced the IL-4 induced CD23 mRNA expression. In contrast, IFN gamma and IFN alpha 2b inhibited IL-4 induced CD23 mRNA expression in normal B lymphocytes. Thus the regulatory effects of IL-4 and interferons on the CD23 membrane expression are linked to an increase and a decrease of CD23 transcripts respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2138708-Antigens, CD,
pubmed-meshheading:2138708-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:2138708-B-Lymphocytes,
pubmed-meshheading:2138708-Humans,
pubmed-meshheading:2138708-Immunoglobulin E,
pubmed-meshheading:2138708-Interferon Type I,
pubmed-meshheading:2138708-Interferon-alpha,
pubmed-meshheading:2138708-Interferon-gamma,
pubmed-meshheading:2138708-Interleukin-4,
pubmed-meshheading:2138708-RNA, Messenger,
pubmed-meshheading:2138708-Receptors, Fc,
pubmed-meshheading:2138708-Receptors, IgE,
pubmed-meshheading:2138708-Recombinant Proteins,
pubmed-meshheading:2138708-Transcription, Genetic
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pubmed:year |
1990
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pubmed:articleTitle |
Interleukin 4 and interferons alpha and gamma regulate Fc epsilon R2/CD23 mRNA expression on normal human B cells.
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pubmed:affiliation |
UNICET, Laboratory for Immunological Research, Dardilly, France.
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pubmed:publicationType |
Journal Article
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