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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0027051,
umls-concept:C0033497,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0308269,
umls-concept:C0936012,
umls-concept:C1101610,
umls-concept:C1554080,
umls-concept:C1706198,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-9
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pubmed:abstractText |
As playing important roles in gene regulation, microRNAs (miRNAs) are believed as indispensable involvers in the pathogenesis of myocardial infarction (MI) that causes significant morbidity and mortality. Working on a hypothesis that modulation of only some key members in the miRNA superfamily could benefit ischemic heart, we proposed a microarray based network biology approach to identify them with the recognized clinical effect of propranolol as a prompt.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21386882-10917072,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e14736
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pubmed:meshHeading |
pubmed-meshheading:21386882-Animals,
pubmed-meshheading:21386882-Anti-Arrhythmia Agents,
pubmed-meshheading:21386882-Disease Models, Animal,
pubmed-meshheading:21386882-Drug Evaluation, Preclinical,
pubmed-meshheading:21386882-Gene Expression Profiling,
pubmed-meshheading:21386882-Gene Expression Regulation,
pubmed-meshheading:21386882-Gene Regulatory Networks,
pubmed-meshheading:21386882-Male,
pubmed-meshheading:21386882-MicroRNAs,
pubmed-meshheading:21386882-Microarray Analysis,
pubmed-meshheading:21386882-Myocardial Infarction,
pubmed-meshheading:21386882-Propranolol,
pubmed-meshheading:21386882-Rats,
pubmed-meshheading:21386882-Rats, Wistar,
pubmed-meshheading:21386882-Validation Studies as Topic
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pubmed:year |
2011
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pubmed:articleTitle |
MicroRNA expression analysis: clinical advantage of propranolol reveals key microRNAs in myocardial infarction.
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pubmed:affiliation |
Institute of Clinical Pharmacology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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