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pubmed-article:21386770pubmed:abstractTextBecause CD4CD25Foxp3 regulatory T cells (Tregs) are essential for the maintenance of self-tolerance, significant interest surrounds the developmental cues for thymic-derived natural Tregs (nTregs) and periphery-generated adaptive Tregs (aTregs). In the transplant setting, the allograft may play a role in the generation of alloantigen-specific Tregs, but this role remains undefined. We examined whether the immune response to a transplant allograft results in the peripheral generation of aTregs.lld:pubmed
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pubmed-article:21386770pubmed:articleTitleGeneration of adaptive regulatory T cells by alloantigen is required for some but not all transplant tolerance protocols.lld:pubmed
pubmed-article:21386770pubmed:affiliationDepartment of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. jkim35@partners.orglld:pubmed
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