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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1990-5-10
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pubmed:abstractText |
The objective of this study was to define the relationship among the circulating insulin level (IRI), the MCR of dehydroepiandrosterone (MCR-D), and the production rate of DHEA (PR-D) in 10 women with the polycystic ovary syndrome and acanthosis nigricans (PCOS-AN). Seven normal weight and 10 obese women served as controls. Measurement of the MCR-D and PR-D was accomplished by iv saline infusion (0.9% NaCl solution) on day 1 as a control and a 4-h iv dehydroepiandrosterone (unlabeled) infusion (1 mg/h) was performed on day 2. Mean MCR-D was more than 2-fold higher in the obese controls compared to the normal weight controls. However, the plasma concentration of DHEA(PC-D) was not significantly different in the normal and obese control women, since the PR-D was increased proportionately to the MCR-D. The MCR-D and the PR-D were coupled through insulin in the control women, and their correlation coefficients with IRI were positive and identical (0.77 and 0.73, respectively). In contrast, IRI was negatively correlated with PR-D in the PCOS-AN women. Also, unlike the control women, there was minimal or no change in the MCR-D across a broad range of IRI in the PCOS-AN women. Thus, the MCR-D and PR-D were not coupled in these women.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1075-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2138630-Acanthosis Nigricans,
pubmed-meshheading:2138630-Adolescent,
pubmed-meshheading:2138630-Adult,
pubmed-meshheading:2138630-Dehydroepiandrosterone,
pubmed-meshheading:2138630-Dehydroepiandrosterone Sulfate,
pubmed-meshheading:2138630-Fasting,
pubmed-meshheading:2138630-Female,
pubmed-meshheading:2138630-Humans,
pubmed-meshheading:2138630-Infusions, Intravenous,
pubmed-meshheading:2138630-Insulin,
pubmed-meshheading:2138630-Metabolic Clearance Rate,
pubmed-meshheading:2138630-Models, Biological,
pubmed-meshheading:2138630-Obesity,
pubmed-meshheading:2138630-Polycystic Ovary Syndrome,
pubmed-meshheading:2138630-Regression Analysis,
pubmed-meshheading:2138630-Statistics as Topic
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pubmed:year |
1990
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pubmed:articleTitle |
Bimodal correlation between the circulating insulin level and the production rate of dehydroepiandrosterone: positive correlation in controls and negative correlation in the polycystic ovary syndrome with acanthosis nigricans.
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pubmed:affiliation |
Department of Medicine, University of Tennessee, Memphis 38163.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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