Linked Life Data

21385708

Source:http://linkedlifedata.com/resource/pubmed/id/21385708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6021
pubmed:dateCreated
2011-3-9
pubmed:abstractText
Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs. In the imaginal discs, proliferative growth is homogeneous in space, posing the conundrum of how morphogen concentration gradients could control position-independent growth. To understand the mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mechanism based on temporal changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism generates position-independent growth rates.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
331
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1154-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Dynamics of Dpp signaling and proliferation control.
pubmed:affiliation
Department of Biochemistry, Faculty of Sciences, Geneva University, 30 Quai Ernest-Ansermet, 1211 Geneva, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't