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pubmed-article:21385406pubmed:abstractTextAutoantibodies against glutamate decarboxylase-65 (GAD??Abs) are thought to be a major immunological tool involved in pathogenic autoimmunity development in various diseases. GAD??Abs are a sensitive and specific marker for type 1 diabetes (T1D). These autoantibodies can also be found in 6-10% of patients classified with type 2 diabetes (T2D), as well as in 1-2% of the healthy population. The latter individuals are at low risk of developing T1D because the prevalence rate of GAD??Abs is only about 0.3%. It has, therefore, been suggested that the antibody binding to GAD?? in these three different GAD??Ab-positive phenotypes differ with respect to epitope specificity. The specificity of reactive oxygen species modified GAD?? (ROS-GAD??) is already well established in the T1D. However, its association in secondary complications of T1D has not yet been ascertained. Hence this study focuses on identification of autoantibodies against ROS-GAD?? (ROS-GAD??Abs) and quantitative assays in T1D associated complications.lld:pubmed
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pubmed-article:21385406pubmed:dateRevised2011-7-27lld:pubmed
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pubmed-article:21385406pubmed:articleTitleDetection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications.lld:pubmed
pubmed-article:21385406pubmed:affiliationDepartment of Biochemistry, Faculty of Medicine and Health Sciences-Gomail, University of Aljabal Algharbil, Zawia-16418, Libya. wajidkhan11@gmail.comlld:pubmed
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