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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-3-24
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pubmed:abstractText |
Autoantibodies against glutamate decarboxylase-65 (GAD??Abs) are thought to be a major immunological tool involved in pathogenic autoimmunity development in various diseases. GAD??Abs are a sensitive and specific marker for type 1 diabetes (T1D). These autoantibodies can also be found in 6-10% of patients classified with type 2 diabetes (T2D), as well as in 1-2% of the healthy population. The latter individuals are at low risk of developing T1D because the prevalence rate of GAD??Abs is only about 0.3%. It has, therefore, been suggested that the antibody binding to GAD?? in these three different GAD??Ab-positive phenotypes differ with respect to epitope specificity. The specificity of reactive oxygen species modified GAD?? (ROS-GAD??) is already well established in the T1D. However, its association in secondary complications of T1D has not yet been ascertained. Hence this study focuses on identification of autoantibodies against ROS-GAD?? (ROS-GAD??Abs) and quantitative assays in T1D associated complications.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-10323459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-10596964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-10753043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-11134126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-11422754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-11916934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-14578287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-14678267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-15046548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-15498046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-18184926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-18543085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-19085183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-19158353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-349081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-7505244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-8015469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-8262321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-942051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21385406-9892215
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2172
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:21385406-Antibody Specificity,
pubmed-meshheading:21385406-Autoantibodies,
pubmed-meshheading:21385406-Diabetes Mellitus, Type 1,
pubmed-meshheading:21385406-Diabetic Nephropathies,
pubmed-meshheading:21385406-Diabetic Retinopathy,
pubmed-meshheading:21385406-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:21385406-Epitopes,
pubmed-meshheading:21385406-Glutamate Decarboxylase,
pubmed-meshheading:21385406-Humans,
pubmed-meshheading:21385406-Pilot Projects,
pubmed-meshheading:21385406-Reactive Oxygen Species
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pubmed:year |
2011
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pubmed:articleTitle |
Detection of autoantibodies against reactive oxygen species modified glutamic acid decarboxylase-65 in type 1 diabetes associated complications.
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pubmed:affiliation |
Department of Biochemistry, Faculty of Medicine and Health Sciences-Gomail, University of Aljabal Algharbil, Zawia-16418, Libya. wajidkhan11@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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