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rdf:type |
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lifeskim:mentions |
umls-concept:C0005955,
umls-concept:C0021757,
umls-concept:C0183683,
umls-concept:C0205314,
umls-concept:C0344211,
umls-concept:C0441655,
umls-concept:C0679622,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1510707,
umls-concept:C1514485,
umls-concept:C1521721
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pubmed:issue |
2
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pubmed:dateCreated |
1990-5-3
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pubmed:abstractText |
The number of colonies produced by bone marrow cells in response to interleukin 3 (IL-3) in soft agar cultures varies according to the strain of the donor mice. A/J, AKR, A.TH and A.TL bone marrow cells are particularly hyporesponsive, producing only occasional colonies in the presence of IL-3. Bone marrow cells from all strains of mice, including A/J, produce distinctively large colonies in response to the combination of IL-3 and macrophage colony stimulating factor (M-CSF). In cultures of A/J bone marrow cells, the synergy between IL-3 and M-CSF is further reflected in an increase in both the number and the variety of colonies produced. The increase in colony numbers may be due to the priming of a population of A/J colony-forming-cells (CFCs) by IL-3, enabling them to respond to M-CSF. In support of this notion, IL-3 enhanced the level of c-fms (M-CSF receptor) messenger RNA in cultures of A/J bone marrow cells. It is also possible that a subpopulation of CFCs requires both IL-3 and M-CSF as co-mitogens. The A/J strain provides a novel system for studying the mechanisms involved in the interaction between IL-3 and M-CSF in haemopoiesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2138495-Animals,
pubmed-meshheading:2138495-Bone Marrow Cells,
pubmed-meshheading:2138495-Cell Division,
pubmed-meshheading:2138495-Cells, Cultured,
pubmed-meshheading:2138495-Colony-Forming Units Assay,
pubmed-meshheading:2138495-Colony-Stimulating Factors,
pubmed-meshheading:2138495-Drug Synergism,
pubmed-meshheading:2138495-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2138495-Growth Substances,
pubmed-meshheading:2138495-Interleukin-3,
pubmed-meshheading:2138495-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2138495-Macrophages,
pubmed-meshheading:2138495-Mice,
pubmed-meshheading:2138495-Mice, Inbred A,
pubmed-meshheading:2138495-Mice, Inbred Strains,
pubmed-meshheading:2138495-Proto-Oncogene Proteins,
pubmed-meshheading:2138495-RNA, Messenger,
pubmed-meshheading:2138495-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:2138495-Species Specificity
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pubmed:year |
1990
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pubmed:articleTitle |
Interleukin 3 alone does not support the proliferation of bone marrow cells from A/J mice: a novel system for studying the synergistic activities of IL-3.
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pubmed:affiliation |
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Woden Valley Hospital, Garran, A.C.T.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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