Linked Life Data

2138444

Source:http://linkedlifedata.com/resource/pubmed/id/2138444

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-4-23
pubmed:abstractText
We examined the distribution of neuropeptide Y immunoreactive local circuit neurons and nonphosphorylated neurofilament (SMI 32) immunoreactive pyramidal projection neurons in superior frontal cortex of patients with Huntington's disease and age-matched control subjects to determine the histological counterpart of increased neuropeptide Y and decrease glutamate concentrations previously found in the cortex of patients with Huntington's disease. We found no difference between the relative density of neuropeptide Y neurons in Huntington's disease and control brains in regions where the relative density of SMI 32 immunoreactive was significantly reduced. Animal studies show that cortical local circuit neurons are resistant to N-methyl-D-aspartate-type excitotoxins such as quinolinic acid. Relative sparing of neuropeptide Y neurons in cerebral cortex with Huntington's disease may, therefore, be a result of excessive N-methyl-D-aspartate receptor activation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0364-5134
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
200-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Degeneration of pyramidal projection neurons in Huntington's disease cortex.
pubmed:affiliation
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't