Source:http://linkedlifedata.com/resource/pubmed/id/21384393
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2011-3-8
|
| pubmed:abstractText |
There is a growing body of evidence suggesting that vascular abnormalities may play crucial role in several dermatologic diseases, such as psoriasis, port wine stain, and skin cancer. To improve our understanding of vascular involvement in these skin conditions, there is a need for a non-invasive imaging modality capable of assessing 3D microcirculations within skin tissue beds in vivo. This study aims to demonstrate whether ultra-high sensitive optical microangiography (UHS-OMAG) is feasible to visualize skin microcirculations in 3D and to quantify microvascular vessel density under normal and psoriatic conditions in vivo. STUDY DESIGN/MATERIAL AND METHODS: An UHS-OMAG system operating at 1,310?nm wavelength was used for in vivo imaging of microcirculation in human skin. The system has a spatial resolution of ?10?µm?×?20?µm (axial?×?lateral), running at 280?fps to acquire 3D imaging dataset to represent morphology and capillary level microvascular blood perfusion within the scanned skin tissue volume. The sensitivity of the system to the blood flow is as low as ?4?µm/second. With this system, we performed the imaging experiments on the skin of a volunteer with stable plaque-type psoriasis. The microcirculation and structural information of normal and diseased skins were compared both qualitatively and quantitatively.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 DC010201-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB009682-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB009682-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB009682-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-01S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL093140-05,
http://linkedlifedata.com/resource/pubmed/grant/R01DC010201,
http://linkedlifedata.com/resource/pubmed/grant/R01EB009682,
http://linkedlifedata.com/resource/pubmed/grant/R01HL093140
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1096-9101
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2011 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
43
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
122-9
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| pubmed:dateRevised |
2011-10-18
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| pubmed:meshHeading |
pubmed-meshheading:21384393-Diagnostic Imaging,
pubmed-meshheading:21384393-Humans,
pubmed-meshheading:21384393-Imaging, Three-Dimensional,
pubmed-meshheading:21384393-Male,
pubmed-meshheading:21384393-Microcirculation,
pubmed-meshheading:21384393-Microvessels,
pubmed-meshheading:21384393-Optical Processes,
pubmed-meshheading:21384393-Psoriasis,
pubmed-meshheading:21384393-Skin
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| pubmed:year |
2011
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| pubmed:articleTitle |
In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography.
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| pubmed:affiliation |
Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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