Linked Life Data

2138413

Source:http://linkedlifedata.com/resource/pubmed/id/2138413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-4-25
pubmed:abstractText
A meta-analysis was performed to determine whether the literature provides evidence that periconceptual or postconceptual maternal use of spermicides is detrimental to the developing fetus. Nine studies that investigated teratogenicity met the inclusion criteria. The Mantel-Haenszel summary odds ratio was 1.02 (95% confidence interval = 0.78 to 1.32). The chi 2 analyses was 0.10 for significance from unity (p = 0.748) and 8.73 for homogeneity of effects (p = 0.365). Studies comparing specific abnormalities with other abnormalities also indicated no association (odds ratio = 0.96; 95% confidence interval = 0.72 to 1.28). Studies investigating other adverse events (spontaneous abortion, stillbirth, reduced fetal weight, prematurity, or increased incidence of female births) showed similar negative results. Cohen's d, the overall effect size as determined by Tukey's jackknife method, was -0.001 (95% confidence interval = -0.018 to 0.017). These results indicate that maternal use of spermicides is not associated with adverse fetal outcomes. Meta-analysis adds quantitative support for conclusions from traditional reviews of the subject.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Maternal spermicide use and adverse reproductive outcome: a meta-analysis.
pubmed:affiliation
Department of Pediatrics, Faculty of Medicine, University of Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Meta-Analysis