Source:http://linkedlifedata.com/resource/pubmed/id/21383243
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2011-3-22
|
| pubmed:databankReference | |
| pubmed:abstractText |
T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that programmed death-1 (PD-1) regulates T cell dysfunction during chronic lymphocytic choriomeningitis virus infection in mice, and PD-1(hi) cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, hepatitis C virus, and hepatitis B virus. However, it is not known if PD-1(hi) cells of healthy humans have the traits of exhausted cells. In this study, we provide a comprehensive description of phenotype, function, and gene expression profiles of PD-1(hi) versus PD-1(lo) CD8 T cells in the peripheral blood of healthy human adults as follows: 1) the percentage of naive and memory CD8 T cells varied widely in the peripheral blood cells of healthy humans, and PD-1 was expressed by the memory CD8 T cells; 2) PD-1(hi) CD8 T cells in healthy humans did not significantly correlate with the PD-1(hi) exhausted gene signature of HIV-specific human CD8 T cells or chronic lymphocytic choriomeningitis virus-specific CD8 T cells from mice; 3) PD-1 expression did not directly affect the ability of CD8 T cells to secrete cytokines in healthy adults; 4) PD-1 was expressed by the effector memory compared with terminally differentiated effector CD8 T cells; and 5) finally, an interesting inverse relationship between CD45RA and PD-1 expression was observed. In conclusion, our study shows that most PD-1(hi) CD8 T cells in healthy adult humans are effector memory cells rather than exhausted cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1550-6606
|
| pubmed:author |
pubmed-author:AhmedRafiR,
pubmed-author:ArakiKoichiK,
pubmed-author:DohoGregory HGH,
pubmed-author:DuraiswamyJaikumarJ,
pubmed-author:FreemanGordon JGJ,
pubmed-author:GuptaSatishS,
pubmed-author:HainingW NicholasWN,
pubmed-author:IbegbuChris CCC,
pubmed-author:MasopustDavidD,
pubmed-author:MillerJoseph DJD,
pubmed-author:NakayaHelder IHI,
pubmed-author:PramilaTataT,
pubmed-author:PulendranBaliB,
pubmed-author:ZillioxMichael JMJ
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
186
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4200-12
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:21383243-Adult,
pubmed-meshheading:21383243-Animals,
pubmed-meshheading:21383243-Antigens, CD,
pubmed-meshheading:21383243-Apoptosis Regulatory Proteins,
pubmed-meshheading:21383243-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21383243-Down-Regulation,
pubmed-meshheading:21383243-G0 Phase,
pubmed-meshheading:21383243-Gene Expression Profiling,
pubmed-meshheading:21383243-Humans,
pubmed-meshheading:21383243-Immunologic Memory,
pubmed-meshheading:21383243-Immunophenotyping,
pubmed-meshheading:21383243-Lymphocyte Activation,
pubmed-meshheading:21383243-Lymphocyte Count,
pubmed-meshheading:21383243-Lymphocytic choriomeningitis virus,
pubmed-meshheading:21383243-Mice,
pubmed-meshheading:21383243-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:21383243-Programmed Cell Death 1 Receptor,
pubmed-meshheading:21383243-T-Lymphocyte Subsets,
pubmed-meshheading:21383243-Up-Regulation
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
|
| pubmed:affiliation |
Emory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|