| pubmed-article:21383242 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1538149 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:21383242 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:21383242 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21383242 | pubmed:dateCreated | 2011-4-5 | lld:pubmed |
| pubmed-article:21383242 | pubmed:abstractText | Conventional and nonconventional T cell development occur in the thymus. Nonconventional thymocytes that bear characteristics typically associated with innate immune cells are termed innate-like lymphocytes (ILLs). Mice harboring a tyrosine to phenylalanine mutation in the adaptor protein Src homology 2 domain-containing leukocyte protein of 76 kDa at residue 145 (Y145F mice) develop an expanded population of CD8(+)CD122(+)CD44(+) ILLs, typified by expression of the T-box transcription factor eomesodermin. Y145F mice also have an expanded population of ?? T cells that produce copious amounts of IL-4 via a mechanism that is dependent on the BTB-ZF transcription factor promyelocytic leukemia zinc finger. Using mice with T cell-specific deletion of Eomes, we demonstrate that this transcription factor is required for CD8(+) ILL development in Y145F as well as wild-type mice. Moreover, we show that promyelocytic leukemia zinc finger and IL-4 are also required for the generation of this ILL population. Taken together, these data shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8(+) ILL differentiation. | lld:pubmed |
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| pubmed-article:21383242 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:21383242 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:21383242 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21383242 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21383242 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:KoretzkyGary... | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:Sant'AngeloDe... | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:ReinerSteven... | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:JordanMartha... | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:CartyShannon... | lld:pubmed |
| pubmed-article:21383242 | pubmed:author | pubmed-author:ZouTaoT | lld:pubmed |
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| pubmed-article:21383242 | pubmed:issnType | Electronic | lld:pubmed |
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| pubmed-article:21383242 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:21383242 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21383242 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21383242 | pubmed:pagination | 4573-8 | lld:pubmed |
| pubmed-article:21383242 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:21383242 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21383242 | pubmed:articleTitle | Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. | lld:pubmed |
| pubmed-article:21383242 | pubmed:affiliation | Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:21383242 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21383242 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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