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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-4-5
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pubmed:abstractText |
Conventional and nonconventional T cell development occur in the thymus. Nonconventional thymocytes that bear characteristics typically associated with innate immune cells are termed innate-like lymphocytes (ILLs). Mice harboring a tyrosine to phenylalanine mutation in the adaptor protein Src homology 2 domain-containing leukocyte protein of 76 kDa at residue 145 (Y145F mice) develop an expanded population of CD8(+)CD122(+)CD44(+) ILLs, typified by expression of the T-box transcription factor eomesodermin. Y145F mice also have an expanded population of ?? T cells that produce copious amounts of IL-4 via a mechanism that is dependent on the BTB-ZF transcription factor promyelocytic leukemia zinc finger. Using mice with T cell-specific deletion of Eomes, we demonstrate that this transcription factor is required for CD8(+) ILL development in Y145F as well as wild-type mice. Moreover, we show that promyelocytic leukemia zinc finger and IL-4 are also required for the generation of this ILL population. Taken together, these data shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8(+) ILL differentiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Eomes protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Kruppel-Like Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLP-76 signal Transducing adaptor...,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zbtb16 protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1550-6606
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pubmed:author |
pubmed-author:AlonzoEric SES,
pubmed-author:CartyShannon ASA,
pubmed-author:GordonScott MSM,
pubmed-author:JordanMartha SMS,
pubmed-author:KimJiyeon SJS,
pubmed-author:KoretzkyGary AGA,
pubmed-author:ReinerSteven LSL,
pubmed-author:Sant'AngeloDerek BDB,
pubmed-author:Smith-GarvinJenniferJ,
pubmed-author:Ts'oDanD,
pubmed-author:ZouTaoT
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4573-8
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21383242-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:21383242-Amino Acid Substitution,
pubmed-meshheading:21383242-Animals,
pubmed-meshheading:21383242-CD4-Positive T-Lymphocytes,
pubmed-meshheading:21383242-CD8-Positive T-Lymphocytes,
pubmed-meshheading:21383242-Cells, Cultured,
pubmed-meshheading:21383242-Flow Cytometry,
pubmed-meshheading:21383242-Interferon-gamma,
pubmed-meshheading:21383242-Interleukin-4,
pubmed-meshheading:21383242-Kruppel-Like Transcription Factors,
pubmed-meshheading:21383242-Mice,
pubmed-meshheading:21383242-Mice, Inbred C57BL,
pubmed-meshheading:21383242-Mice, Knockout,
pubmed-meshheading:21383242-Mutation,
pubmed-meshheading:21383242-Phosphoproteins,
pubmed-meshheading:21383242-T-Box Domain Proteins,
pubmed-meshheading:21383242-Thymus Gland,
pubmed-meshheading:21383242-Zinc Fingers
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pubmed:year |
2011
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pubmed:articleTitle |
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.
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pubmed:affiliation |
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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