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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
7
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|
pubmed:dateCreated |
2011-4-7
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pubmed:abstractText |
A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates of the most potent compounds 4 and 7 were separated and tested, but no enantioselectivity was found for the nootropic activity. Compounds 4 and 7 and their enantiomers displayed interesting antihyperalgesic activity in two models of neuropathic pain (streptozotocin-induced and oxalilplatin-induced neuropathy) in comparison with pregabalin.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
1520-4804
|
|
pubmed:author |
pubmed-author:BartolucciGianlucaG,
pubmed-author:BertucciCarloC,
pubmed-author:DeiSilviaS,
pubmed-author:Di Cesare MannelliLorenzoL,
pubmed-author:GhelardiniCarlaC,
pubmed-author:GuandaliniLucaL,
pubmed-author:ManettiDinaD,
pubmed-author:MartiniElisabettaE,
pubmed-author:RomanelliMaria NovellaMN,
pubmed-author:ScapecchiSerenaS,
pubmed-author:TeodoriElisabettaE
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|
pubmed:issnType |
Electronic
|
|
pubmed:day |
14
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2512-6
|
|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21381762-Amnesia,
pubmed-meshheading:21381762-Analgesics,
pubmed-meshheading:21381762-Animals,
pubmed-meshheading:21381762-Behavior, Animal,
pubmed-meshheading:21381762-Drug Design,
pubmed-meshheading:21381762-Ketones,
pubmed-meshheading:21381762-Mice,
pubmed-meshheading:21381762-Nootropic Agents,
pubmed-meshheading:21381762-Scopolamine Hydrobromide,
pubmed-meshheading:21381762-Stereoisomerism
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pubmed:year |
2011
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|
pubmed:articleTitle |
Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
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pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
