Linked Life Data

21381684

Source:http://linkedlifedata.com/resource/pubmed/id/21381684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2011-4-25
pubmed:abstractText
Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8?-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8?-(benzoyloxy)methyl-2?-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8?-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2?-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 ?mol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
650-7
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
In vivo activity of benzoyl ester clerodane diterpenoid derivatives from Dodonaea polyandra.
pubmed:affiliation
Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide, 5000, South Australia. bradley.simpson@unisa.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't