Linked Life Data

2138029

Source:http://linkedlifedata.com/resource/pubmed/id/2138029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-4-20
pubmed:abstractText
Epidemiological and experimental studies suggest that androgens influence colonic carcinogenesis. We investigated the effects of hormonal manipulations (surgical and chemical castration, hormone substitution) on colonic tumour development, tumour and mucosal histopathology, and epithelial proliferation in macroscopically normal colonic mucosa in male rats, after induction of chemical colon carcinogenesis by subcutaneous injections of azoxymethane (AOM). Chemical castration with cyproterone acetate, but not surgical castration, resulted in increased colonic tumorigenesis, which was accompanied by decreased crypt length, decreased number of cells per crypt, and increased crypt epithelial mitotic index in the right colon. Chemically castrated rats also had crypt hyperplasia and increased numbers of dysplastic foci in the left colon which were not seen with surgical castration. By contrast, rats given testosterone after surgical castration showed decreased colonic tumorigenesis with an increased proportion of tumours in the left colon and lower percentage of tumours with invasion. The grossly normal mucosa of the testosterone-substituted castrated rats showed decreased crypt length in the right colon similar to the other groups of castrated rats, but no significant increase in mitotic index. Our results suggest that the anti-androgenic progestin cyproterone is a potent enhancer of colonic tumorigenesis and epithelial proliferative abnormalities after AOM administration. Exogenous testosterone after castration alters tumour distribution and characteristics and suppresses epithelial proliferative abnormalities. Finally, androgen effects on the colonic mucosa are more prominent in the right than in the left colon, suggesting different influences of hormones on the epithelium of these anatomical sites.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-13377228, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-13659539, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-3291747, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-427738, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-6348673, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-6499618, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-6517532, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-6578365, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-6616504, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-7006791, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-7096124, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-7149648, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-7151066, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-7357503, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-845981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2138029-922691
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of androgen manipulations on chemically induced colonic tumours and on macroscopically normal colonic mucosa in male Sprague-Dawley rats.
pubmed:affiliation
Dept of Surgery, University of Munich, FR Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't