Linked Life Data

21378092

Source:http://linkedlifedata.com/resource/pubmed/id/21378092

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-4-14
pubmed:abstractText
Thyroid function is tightly regulated by TSH. Although individual follicles are exposed to the same blood supply of TSH and express relatively homogenous levels of the TSH receptor, the function of individual follicles is variable. It was shown that thyroglobulin (Tg), stored in the follicular lumen, is a potent negative feedback regulator of follicular function. Thus, physiological concentrations of Tg significantly suppress thyroid-specific gene expression and antagonize the TSH-mediated stimulation that induces expression of thyroid-specific genes. Tg coordinately regulates both basal and apical iodide transporters in thyroid follicular cells. Recently, it was also reported that Tg could induce thyroid cell growth in the absence of TSH. These results indicate that Tg is an essential autocrine regulator of physiological thyroid follicular function that counteracts the effects of TSH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1479-6805
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-74
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Role of thyroglobulin on negative feedback autoregulation of thyroid follicular function and growth.
pubmed:affiliation
Laboratory of Molecular Diagnostics, Department of Mycobacteriology, National Institute of Infectious Diseases, Leprosy Research Center, Higashimurayama, Tokyo 189-0002, Japan. koichis@nih.go.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't