Linked Life Data

21376929

Source:http://linkedlifedata.com/resource/pubmed/id/21376929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-3-7
pubmed:abstractText
Even among asymptomatic persons at low risk (<10%) according to the Framingham risk score, high coronary artery calcium (CAC) scores signify a greater predicted risk of coronary heart disease events. We sought to determine the noninvasive factors (without radiation exposure) significantly associated with CAC in low-risk, asymptomatic persons. In a cross-sectional analysis, we studied 3,046 participants from the Multi-Ethnic Study of Atherosclerosis at a low 10-year predicted risk (Framingham risk score <10%) of coronary heart disease events. Multivariate logistic regression analysis was used to assess the association of novel markers with the presence of any CAC (CAC >0) and advanced CAC (CAC ? 300). A CAC level of >0 and of ? 300 was present in 30% and 3.5% of participants, respectively. Factor VIIIc, fibrinogen, and soluble intercellular adhesion molecule were each associated with the presence of CAC (p ? 0.02), and C-reactive protein, D-dimer, and the carotid intima-media thickness with advanced CAC (p ? 0.03). The base model combining the traditional risk factors had excellent discrimination for advanced CAC (C-statistic 0.808). The addition of the 2 best-fit models combining the biomarkers with or without carotid intima-media thickness improved the c-statistic to 0.822 and 0.820, respectively. All 3 models calibrated well but were similar in estimating the individual risk probabilities for advanced CAC (prevalence 9.97%, 10.63%, and 10.10% in the greatest quartiles of predicted probabilities vs 0.26%, 0.26%, and 0.26% in the lowest quartiles, respectively). In conclusion, in low-risk persons, the traditional risk factors alone predicted advanced CAC with high discrimination and calibration. The biomarker combinations with and without carotid intima-media thickness were also significantly associated with advanced CAC; however, the improvement in the prediction and estimation of the clinical risk were modest compared to the traditional risk factors alone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1879-1913
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
879-85
pubmed:dateRevised
2011-9-30
pubmed:meshHeading
pubmed-meshheading:21376929-Aged, pubmed-meshheading:21376929-Aged, 80 and over, pubmed-meshheading:21376929-Biological Markers, pubmed-meshheading:21376929-Calcinosis, pubmed-meshheading:21376929-Coronary Disease, pubmed-meshheading:21376929-Cross-Sectional Studies, pubmed-meshheading:21376929-Diagnostic Imaging, pubmed-meshheading:21376929-Female, pubmed-meshheading:21376929-Humans, pubmed-meshheading:21376929-Logistic Models, pubmed-meshheading:21376929-Male, pubmed-meshheading:21376929-Middle Aged, pubmed-meshheading:21376929-Predictive Value of Tests, pubmed-meshheading:21376929-Prospective Studies, pubmed-meshheading:21376929-Risk Assessment, pubmed-meshheading:21376929-Risk Factors, pubmed-meshheading:21376929-Tunica Intima, pubmed-meshheading:21376929-Tunica Media, pubmed-meshheading:21376929-United States
pubmed:year
2011
pubmed:articleTitle
Factors associated with presence and extent of coronary calcium in those predicted to be at low risk according to Framingham risk score (from the Multi-Ethnic Study of Atherosclerosis).
pubmed:affiliation
Division of Cardiology, Wayne State University School of Medicine, Detroit, MI, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural