Linked Life Data

21376669

Source:http://linkedlifedata.com/resource/pubmed/id/21376669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-30
pubmed:abstractText
The laminated layer (LL) is the massive carbohydrate-rich structure that protects Echinococcus larvae, which cause cystic echinococcosis (hydatid disease) and alveolar echinococcosis. Increased understanding of the biochemistry of the LL is allowing a more informed analysis of its immunology. The LL not only protects the parasite against host attack but also shapes the overall immune response against it. Because of its dense glycosylation, it probably contains few T-cell epitopes, being important instead in T-cell independent antibody responses. Crucially, it is decoded in non-inflammatory fashion by innate immunity, surely contributing to the strong immune-regulation observed in Echinococcus infections. Defining the active LL molecular motifs and corresponding host innate receptors is a feasible and promising goal in the field of helminth-derived immune-regulatory molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1471-5007
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-73
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Understanding the laminated layer of larval Echinococcus II: immunology.
pubmed:affiliation
Cátedra de Inmunología. Departamento de Biociencias, Facultad de Química/IQB, Facultad de Ciencias. Universidad de la República, Montevideo CP 11600, Uruguay. adiaz@fq.edu.uy
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't