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rdf:type |
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lifeskim:mentions |
umls-concept:C0012899,
umls-concept:C0030705,
umls-concept:C0205179,
umls-concept:C0205210,
umls-concept:C0332293,
umls-concept:C0439743,
umls-concept:C0681890,
umls-concept:C1261473,
umls-concept:C1274040,
umls-concept:C1311070,
umls-concept:C1514923,
umls-concept:C2603343
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pubmed:issue |
7
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pubmed:dateCreated |
2011-4-5
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pubmed:abstractText |
Trabectedin sensitivity is increased in cells with functional nucleotide excision DNA repair, whereas efficient homologous recombination repair leads to resistance. On this basis, a retrospective study of mRNA expression of BRCA1 (breast cancer susceptibility 1 gene), XPG (Xeroderma pigmentosum group G gene) and ERCC1 (excision-repair cross complementing group 1 gene) in tumour samples from sarcoma patients treated with trabectedin was conducted, to correlate DNA repair profiles with patient outcome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA excision repair protein ERCC-5,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxoles,
http://linkedlifedata.com/resource/pubmed/chemical/ERCC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/trabectedin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1879-0852
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pubmed:author |
pubmed-author:BlayJ-YJY,
pubmed-author:CasaliP GPG,
pubmed-author:GrossoFF,
pubmed-author:JimenoJJ,
pubmed-author:JonesR LRL,
pubmed-author:Le CesneAA,
pubmed-author:MakiR GRG,
pubmed-author:NietoAA,
pubmed-author:PovedaAA,
pubmed-author:RosellRR,
pubmed-author:SanfilipioRR,
pubmed-author:SchöffskiPP,
pubmed-author:TaronMM,
pubmed-author:TerceroJ CJC
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1006-12
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pubmed:meshHeading |
pubmed-meshheading:21376569-Antineoplastic Agents, Alkylating,
pubmed-meshheading:21376569-BRCA1 Protein,
pubmed-meshheading:21376569-DNA Repair,
pubmed-meshheading:21376569-DNA-Binding Proteins,
pubmed-meshheading:21376569-Dioxoles,
pubmed-meshheading:21376569-Endonucleases,
pubmed-meshheading:21376569-Female,
pubmed-meshheading:21376569-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21376569-Humans,
pubmed-meshheading:21376569-Male,
pubmed-meshheading:21376569-Nuclear Proteins,
pubmed-meshheading:21376569-RNA, Messenger,
pubmed-meshheading:21376569-Recombination, Genetic,
pubmed-meshheading:21376569-Retrospective Studies,
pubmed-meshheading:21376569-Sarcoma,
pubmed-meshheading:21376569-Tetrahydroisoquinolines,
pubmed-meshheading:21376569-Transcription Factors,
pubmed-meshheading:21376569-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: a retrospective multicentric study.
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pubmed:affiliation |
Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, B-3000 Leuven, Belgium. patrick.schoffski@uzleuven.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural
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