pubmed:abstractText |
2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis has been used as an inflammatory bowel disease (IBD), Crohn's disease (CD), preclinical model. However, published data on pharmacologic and therapeutic efficacy testing of this model are limited. FTY720 inhibits lymphoid cell trafficking in inflammatory conditions and is of interest to treat IBD.
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pubmed:affiliation |
Drug Safety R&D, Pfizer Worldwide Research and Development, 35 CambridgePark Dr, Cambridge, MA 02140, USA. zaher.radi@pfizer.com
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