Linked Life Data

21371906

Source:http://linkedlifedata.com/resource/pubmed/id/21371906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-3-30
pubmed:abstractText
Previous studies suggest a role for IL-1? in the pathophysiology of upper extremity soft tissue disorders (UESTDs). We studied the levels of interleukin-1 family members in patients with incipient UESTDs and compared them with healthy controls. In this case control study, we included 163 patients with UESTDs and symptom duration shorter than 1 month and 42 healthy controls matched for age and gender at the group level. Serum levels of cytokines IL-1?, IL-1?, IL-1Ra, IL-6, IL-8, IL-18, IL-33, TNF? and sensitized C-reactive protein as well as IL-1 family soluble receptors sIL-1RII and sST2 were assessed. We used unconditional logistic regression models to study the associations between cytokines and UESTDs. After adjustment for potential confounders, the serum levels of sIL-1RII (p<0.001) and sST2 (p=0.014) were higher in the patients than the controls. The level of IL-18 was lower in the patients than the controls (p=0.005). There were no significant differences between the patients and controls regarding the levels of IL-1?, IL-1?, IL-1Ra, IL-33, IL-6, IL-8, TNF?, or sensitized C-reactive protein. The levels of circulating sIL-1RII and IL-18 are associated with incipient UESTDs, suggesting an important role for these IL-1 family members in the early course of UESTDs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1096-0023
pubmed:author
pubmed:copyrightInfo
Copyright © 2011 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-53
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.
pubmed:affiliation
Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland. martti.rechardt@ttl.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't